August 30, 2010
Sulfanilamide was one of the earliest sulfonamide antimicrobials. It was first synthesized in 1908 by P. Gelmo and first used as a chemotherapeutic agent in 1935 by G. Domagk, J. Trefouel, and T. Trefouel. They thought that the drug was a complex sulfonamide; but it was later shown that its metabolite, sulfanilamide, was the true active substance.
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