IREU Summer Research Projects: CPE-Lyon (France)
U.S. undergraduate students may apply for one of the following IREU summer projects at the CPE-Lyon in Villeurbanne, France.
See available research projects at:
- University of Perugia (Perugia, Italy)
- University of Strathclyde (Scotland, UK)
- Germany institutions (Visit the German Academic Exchange Service).
CPE-Lyon Summer Research Projects
Application Instructions
| Project Code | Project Title |
Professor |
| CPE. 1 | Synthesis of a Library of Bistramide A analogs | Prof. Peter Goekjian and Dr. David Gueyrard, in collaboration with Janet Lord, Birmingham University; Jari Yli-Kauhaluoma, University of Helsinki; Olivier Piva, Universite Claude Bernard - Lyon |
| CPE. 2 | Total Synthesis of Attenol A | Dr. David Gueyrard and Prof. Peter Goekjian |
| CPE. 3 | Total Synthesis of Broussonetine H and N | Dr. David Gueyrard and Prof. Peter Goekjian |
(CPE. 1) Synthesis of a Library of Bistramide A analogs
Prof. Peter Goekjian and Dr. David Gueyrard, in collaboration with Janet Lord, Birmingham University; Jari Yli-Kauhaluoma, University of Helsinki; Olivier Piva, Universite Claude Bernard - Lyon 1
Bistramide A is a marine natural product with a dual mode of action. It was originally identified as a specific PKC-delta activator, but recent studies by Kozmin et al. have identified actin as a principal target. We have recently completed the total synthesis of Bistramide A, and are interested in preparing a library of analogs in order to further probe the biological activity: Can we identify analogs that bind to actin, but do not activate PKC-delta? Similarly, can we identify analogs that activate PKC-delta but do not bind actin?
The synthesis is based on the preparation of spiroketals from carbohydrate derived lactones via exo-enol ethers, while the tetrahydropyran system is prepared by a kinetically controlled oxa-Michael cyclization. Different methods will be used to couple the three fragments.
(CPE. 2) Total Synthesis of Attenol A
Dr. David Gueyrard and Prof. Peter Goekjian
L’Attenol A was isolated in 1999 from Pinna attenuata and showed cytotoxic activity against P388 Leukemia cells. A total synthesis will be performed via the corresponding exo-cyclic enol ether.
(CPE. 3) Total Synthesis of Broussonetine H and N
Dr. David Gueyrard and Prof. Peter Goekjian
Broussenetine H and N will each be synthesized by coupling of a spiroketal fragment derived from valerolactone and a carbohydrate-derived pyrrolidine.
